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Sample size calculations for clustered and longitudinal outcomes in clinical research / Chul Ahn, Moonseoung Heo and Song Zhang.

By: Contributor(s): Material type: TextTextSeries: Chapman & Hall/CRC biostatistics seriesPublication details: Boca Raton : CRC Press, c2015.Description: xv, 244 p. : illustrations ; 24 cmISBN:
  • 9781466556263 (hardback)
Subject(s): DDC classification:
  • 000SB:610 23 Ah286
Contents:
1. Sample size determination for independent outcomes -- 2. Sample size determination for clustered outcomes -- 3. Sample size determination for repeated measurement outcomes using summary statistics -- 4. Sample size determination for correlated outcome measurements using GEE -- 5. Sample size determination for correlated outcomes from two-level randomized clinical trials -- 6. Sample size determination for correlated outcomes from three-level randomized clinical trials-- Index.
Summary: The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement.
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Holdings
Item type Current library Call number Status Date due Barcode Item holds
Books ISI Library, Kolkata 000SB:610 Ah286 (Browse shelf(Opens below)) Available 136412
Total holds: 0

Includes bibliographical references and index.

1. Sample size determination for independent outcomes --
2. Sample size determination for clustered outcomes --
3. Sample size determination for repeated measurement outcomes using summary statistics --
4. Sample size determination for correlated outcome measurements using GEE --
5. Sample size determination for correlated outcomes from two-level randomized clinical trials --
6. Sample size determination for correlated outcomes from three-level randomized clinical trials--
Index.

The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement.

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