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Adaptive and flexible clinical trials / Richard Chin.

By: Material type: TextTextPublication details: Boca Raton, Fla. : CRC Press, 2012.Description: xiii, 184 p. : ill. ; [ca. 23-29] cmISBN:
  • 9781439838327
Subject(s): Available additional physical forms:
  • Also available as an electronic resource.
Contents:
1. Background -- 2. Conventional statistics -- 3. Statistics used in adaptive clinical trials -- 4. Specific requirements for adaptive trials -- 5. Adaptive randomization and allocation -- 6. Sample size reestimation -- 7. Traditional dosing -- 8. Adaptive dosing -- 9. Interim analysis and adaptive termination of study and study arms -- 10. Adaptive changes in study design and decision rules -- 11. Seamless designs and adaptive clinical trial conduct -- 12. Analysis and interpretation of results.
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"A Chapman & Hall book."

Includes bibliographical references and index.

1. Background -- 2. Conventional statistics -- 3. Statistics used in adaptive clinical trials -- 4. Specific requirements for adaptive trials -- 5. Adaptive randomization and allocation -- 6. Sample size reestimation -- 7. Traditional dosing -- 8. Adaptive dosing -- 9. Interim analysis and adaptive termination of study and study arms -- 10. Adaptive changes in study design and decision rules -- 11. Seamless designs and adaptive clinical trial conduct -- 12. Analysis and interpretation of results.

Also available as an electronic resource.

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