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Genomics of pattern recognition receptors : applications in oncology and cardiovascular diseases / Anton G. Kutikhin and Arseniy E. Yuzhalin.

By: Contributor(s): Material type: TextTextPublication details: New York : Springer, 2013.Description: xi, 185 p. ; illustrationsISBN:
  • 9783034806879
Subject(s): DDC classification:
  • 572.696 23 K97
Contents:
1. The Biology of Toll-Like Receptors and NOD-Like Receptors: The Toggles of Inflammation -- 2. Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- 3. Structural Genomic Variation in TLR4 Gene and Cancer -- 4. Structural Genomic Variation in Other Toll-Like Receptors and Cancer -- 5. Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- 6. Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- 7. Structural Genomic Variation in NOD-Like Receptors and Cancer -- 8. Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- 9. Hot Spots in the Field: Where Should We Go?-- Index.
Summary: This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
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Holdings
Item type Current library Call number Status Date due Barcode Item holds
Books ISI Library, Kolkata 572.696 K97 (Browse shelf(Opens below)) Available 136142
Total holds: 0

Includes index.

1. The Biology of Toll-Like Receptors and NOD-Like Receptors: The Toggles of Inflammation --
2. Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword --
3. Structural Genomic Variation in TLR4 Gene and Cancer --
4. Structural Genomic Variation in Other Toll-Like Receptors and Cancer --
5. Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer --
6. Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer --
7. Structural Genomic Variation in NOD-Like Receptors and Cancer --
8. Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases --
9. Hot Spots in the Field: Where Should We Go?--
Index.

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

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