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Mendelian randomization : methods for using genetic variants in causal estimation / Stephen Burgess and Simon G. Thompson.

By: Contributor(s): Material type: TextTextSeries: Chapman & Hall/CRC interdisciplinary statistics seriesPublication details: Boca Raton : CRC Press, ©2015.Description: xiv, 210 p. : illustrations ; 24 cmISBN:
  • 9781466573178
Subject(s): DDC classification:
  • 000SB:616.042 23 B955
Contents:
1. Introduction and motivation -- 2. What is Mendelian randomization? -- 3. Assumptions for causal inference -- 4. Methods for instrumental variable analysis -- 5. Examples of Mendelian randomization analysis -- 6. Generalization of estimates from Mendelian randomization -- 7. Weak instruments and finite-sample bias -- 8. Multiple instruments and power -- 9. Multiple studies and evidence synthesis -- 10. Example: The CRP CHD genetics collaboration -- 11. Future directions.
Summary: This book gives statisticians, epidemiologists, and geneticists the foundation to understand issues concerning the use of genetic variants as instrumental variables. It will get them up to speed in undertaking and interpreting Mendelian randomization analyses.
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Holdings
Item type Current library Call number Status Date due Barcode Item holds
Books ISI Library, Kolkata 000SB:616.042 B955 (Browse shelf(Opens below)) Available 137277
Total holds: 0

Includes bibliographical references and index.

1. Introduction and motivation --
2. What is Mendelian randomization? --
3. Assumptions for causal inference --
4. Methods for instrumental variable analysis --
5. Examples of Mendelian randomization analysis --
6. Generalization of estimates from Mendelian randomization --
7. Weak instruments and finite-sample bias --
8. Multiple instruments and power --
9. Multiple studies and evidence synthesis --
10. Example: The CRP CHD genetics collaboration --
11. Future directions.

This book gives statisticians, epidemiologists, and geneticists the foundation to understand issues concerning the use of genetic variants as instrumental variables. It will get them up to speed in undertaking and interpreting Mendelian randomization analyses.

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