Mendelian randomization : methods for using genetic variants in causal estimation / Stephen Burgess and Simon G. Thompson.
Material type:
TextSeries: Chapman & Hall/CRC interdisciplinary statistics seriesPublication details: Boca Raton : CRC Press, ©2015.Description: xiv, 210 p. : illustrations ; 24 cmISBN: - 9781466573178
- 000SB:616.042 23 B955
| Item type | Current library | Call number | Status | Date due | Barcode | Item holds | |
|---|---|---|---|---|---|---|---|
| Books | ISI Library, Kolkata | 000SB:616.042 B955 (Browse shelf(Opens below)) | Available | 137277 |
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| 000SB:616.994 In61 Probability models and cancer | 000SB:616.994 T473 Cancer modeling | 000SB:616.995 T916 lack of sensitization following repeated skin tests with standard tuberculin (PPD-S) | 000SB:616.042 B955 methods for using genetic variants in causal estimation / | 000SB:616.8 C518 Advanced state space methods for neural and clinical data / | 000SB:616.804754 C559 Statistical and computational methods in brain image analysis / | 000SB:616.9 B395 Modeling to inform infectious disease control / |
Includes bibliographical references and index.
1. Introduction and motivation --
2. What is Mendelian randomization? --
3. Assumptions for causal inference --
4. Methods for instrumental variable analysis --
5. Examples of Mendelian randomization analysis --
6. Generalization of estimates from Mendelian randomization --
7. Weak instruments and finite-sample bias --
8. Multiple instruments and power --
9. Multiple studies and evidence synthesis --
10. Example: The CRP CHD genetics collaboration --
11. Future directions.
This book gives statisticians, epidemiologists, and geneticists the foundation to understand issues concerning the use of genetic variants as instrumental variables. It will get them up to speed in undertaking and interpreting Mendelian randomization analyses.
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