Genome stability : from virus to human application / [edited by] Igor Kovalchuk and Olga Kovalchuk.

Includes bibliographical references and index.

Section I: Genome instability of viruses --
Section II: Genome instability in bacteria and archaea --
Section III: Genome stability of unicellular eukaryotes --
Section IV: Genome stability in multicellular eukaryotes --
Section V: Genome stability in mammals --
Section VI: Human diseases associated with genome instability --
Section VII: Effect of environment on genome stability --
Section VIII: Bystander and transgenerational effects- epigenetic perspective.

Genome Stability: From Virus to Human Application covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner.