TY  - BOOK
AU  - Chow,Shein-Chung
AU  - Chang,Mark
TI  - Adaptive design methods in clinical trials
T2  - Chapman & Hall/CRC biostatistics series
SN  - 9781439839874
PY  - 2012///
CY  - Boca Raton
PB  - Taylor & Francis
KW  - Clinical trials
KW  - Adaptive sampling (Statistics)
KW  - Experimental design
KW  - Statistical methods
N1  - Includes bibliographical references and index; Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance; Also available as an electronic resource
ER  -