TY  - BOOK
AU  - Chow,Shein-Chung
AU  - Liu,Jen-Pei
TI  - Design and analysis of clinical trials: concepts and methodologies 
T2  - Wiley series in probability and statistics
SN  - 9780470887653 (cloth)
U1  - 000SB:610.724 23
PY  - 2014///
CY  - New Jersey
PB  - John Wiley
KW  - Clinical trials
KW  - Methodology
KW  - Statistical methods
N1  - Includes bibliographical references (p. 799-844) and index; 1. Introduction--
2. Basic statistical concepts--
3. Basic design considerations--
4. Randomization and blinding--
5. Designs for clinical trials--
6. Designs for cancer clinical trials--
7. Classification of clinical trials--
8. Analysis of continuous data--
9. Analysis of categorical data--
10. Censored data and interim analysis--
11. Sample size determination--
12. Issues in efficacy evaluation--
13. Safety assessment--
14. Biomarkers and targeted clinical trials--
15. Trials for evaluating accuracy of diagnostic devices--
16. Statistical methods in translational medicine--
17. Adaptive clinical trial designs--
18. Traditional Chinese medicine--
19. Preparation and implementation of a clinical protocol--
20. Data management of clinical trial--
References--
Appendix A--
Index

N2  - Praise for the Second Edition: " ... a grand feast for biostatisticians. It stands ready to satisfy the appetite of any pharmaceutical scientist with a respectable statistical appetite."--Journal of Clinical Research Best Practices The Third Edition of Design and Analysis of Clinical Trials provides complete, comprehensive, and expanded coverage of recent health treatments and interventions. Featuring a unified presentation, the book provides a well-balanced summary of current regulatory requirements and recently developed statistical methods as well as.
ER  -