TY  - BOOK
AU  - Kutikhin,Anton G.
AU  - Yuzhalin,Arseniy E.
TI  - Genomics of pattern recognition receptors : : applications in oncology and cardiovascular diseases 
SN  - 9783034806879
U1  - 572.696 23
PY  - 2013///
CY  - New York :   
PB  - Springer,  
KW  - Pattern Recognition Receptors.
KW  - Genomics.
KW  - Cardiovascular Diseases
KW  - therapy
N1  - Includes index; 1. The Biology of Toll-Like Receptors and NOD-Like Receptors: The Toggles of Inflammation --
2. Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword --
3. Structural Genomic Variation in TLR4 Gene and Cancer --
4. Structural Genomic Variation in Other Toll-Like Receptors and Cancer --
5. Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer --
6. Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer --
7. Structural Genomic Variation in NOD-Like Receptors and Cancer --
8. Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases --
9. Hot Spots in the Field: Where Should We Go?--
Index
N2  - This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
ER  -