TY - BOOK AU - Ahn,Chul AU - Heo,Moonseoung AU - Zhang,Song TI - Sample size calculations for clustered and longitudinal outcomes in clinical research T2 - Chapman & Hall/CRC biostatistics series SN - 9781466556263 (hardback) U1 - 000SB:610 23 PY - 2015/// CY - Boca Raton PB - CRC Press, KW - Clinical medicine KW - Research KW - Statistical methods KW - Sampling (Statistics) N1 - Includes bibliographical references and index; 1. Sample size determination for independent outcomes -- 2. Sample size determination for clustered outcomes -- 3. Sample size determination for repeated measurement outcomes using summary statistics -- 4. Sample size determination for correlated outcome measurements using GEE -- 5. Sample size determination for correlated outcomes from two-level randomized clinical trials -- 6. Sample size determination for correlated outcomes from three-level randomized clinical trials-- Index N2 - The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement ER -