TY  - BOOK
AU  - Ahn,Chul
AU  - Heo,Moonseoung
AU  - Zhang,Song
TI  - Sample size calculations for clustered and longitudinal outcomes in clinical research
T2  - Chapman & Hall/CRC biostatistics series
SN  - 9781466556263 (hardback)
U1  - 000SB:610 23
PY  - 2015///
CY  - Boca Raton
PB  - CRC Press, 
KW  - Clinical medicine
KW  - Research
KW  - Statistical methods
KW  - Sampling (Statistics)
N1  - Includes bibliographical references and index; 1. Sample size determination for independent outcomes --
 2. Sample size determination for clustered outcomes --
 3. Sample size determination for repeated measurement outcomes using summary statistics --
 4. Sample size determination for correlated outcome measurements using GEE --
 5. Sample size determination for correlated outcomes from two-level randomized clinical trials --
 6. Sample size determination for correlated outcomes from three-level randomized clinical trials--
Index
N2  - The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement
ER  -