TY  - BOOK
AU  - Dye,Christopher
TI  - Population biology of tuberculosis
T2  - Monographs in population biology
SN  - 9780691154626 (hardcover : alk. paper)
U1  - 614.542 23
PY  - 2015///
CY  - Princeton
PB  - Princeton University Press
KW  - Tuberculosis
KW  - Epidemiology.
KW  - Mycobacterium tuberculosis.
N1  - Includes bibliographical references and index; 1. Tuberculosis undefeated --
2. Concepts and models --
3. Risk and variation --
4. Interventions and control --
5. Strains and drug resistance --
6. TB and HIV/AIDS --
7. Elimination and eradication --
8. Populations and social diseases --
Appendices
N2  - This book examines why the disease is so persistent and what must be done to fight it. Treating tuberculosis and its human hosts as dynamic, interacting populations, Christopher Dye seeks new answers to key questions by drawing on demography, ecology, epidemiology, evolution, and population genetics. Dye uses simple mathematical models to investigate how cases and deaths could be reduced, and how interventions could lead to TB elimination. Dye's analysis reveals a striking gap between the actual and potential impact of current interventions, especially drug treatment, and he suggests placing more emphasis on early case detection and the treatment of active or incipient tuberculosis. He argues that the response to disappointingly slow rates of disease decline is not to abandon long-established principles of chemotherapy, but to implement them with greater vigor. Summarizing epidemiological insights from population biology, Dye stresses the need to take a more inclusive view of the factors that affect disease, including characteristics of the pathogen, individuals and populations, health care systems, and physical and social environments. In broadening the horizons of TB research, The Population Biology of Tuberculosis demonstrates what must be done to prevent, control, and defeat this global threat in the twenty-first century
ER  -