TY  - BOOK
AU  - Piantadosi,Steven
TI  - Clinical trials: a methodologic perspective 
T2  - Wiley series in probability and statistics
SN  - 9781118959206 
U1  - 000SB:610.72 23
PY  - 2017///
CY  - Hoboken, NJ : 
PB  - John Wiley & Sons, 
KW  - Clinical trials
KW  - Statistical methods
N1  - Includes bibliographical references and index; 1. Preliminaries --
2. Clinical trials as research --
3. Why clinical trials are ethical --
4. Contexts for clinical trials --
5. Measurement --
6. Random error and bias --
7. Statistical perspectives --
8. Experimental designs in clinical trials --
9. The trial cohort --
10. Development paradigms --
11.  Translational clinical trials --
12. Early development and dose-finding designs --
13. Middle development --
14. Comparative trials --
15. Adaptive design features --
16.  Sample size and power --
17. Treatment allocation --
18. Treatment effects monitoring --
19. Counting subjects and events --
20. Estimating clinical effects --
21. Prognostic factor analyses --
22. Factorial designs --
23. Crossover designs --
24. Meta-analyses --
25. Reporting and authorship --
26. Misconduct and fraud in clinical research.
Appendices.
N2  - This Third Edition of the critically hailed Clinical Trials builds on the text's reputation as a straightforward and authoritative presentation of statistical methods for clinical trials
ER  -